Psychedelic therapy in the treatment of addiction: the past, present and future
These results demonstrate functional selectivity at the 5-HT2A receptor, in which serotonin and its N-methylated derivatives promote differential signaling in the mouse frontal cortex and in primary cortical neurons and thus have different mechanisms underlying manifestation of the HTR. That is, serotonin activation leads to a signaling complex that involves β-arrestin-2, Src, and Akt, whereas …
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